Brad Pitt was married to Jennifer Aniston at the time, but "Brangelina" was meant to be.
Reportedly, Meg Ryan and Dennis Quaid’s marriage was already on the rocks before this movie was shot, with Quaid allegedly cheating on Ryan.
Then the actress met Russell Crowe while filming 'Proof of Life' and their chemistry was instant, even though the romance between the co-stars didn't last.
The movie that famously brought Brad Pitt and Angelina Jolie together also famously destroyed the actor's marriage.
But while Ryan and Crowe didn't stay together, Meg Ryan and Dennis Quaid ended up getting divorced in 2001.
Kenneth Branagh was married to Emma Thompson when he fell for his co-star Helena Bonham Carter.
An affair between the two prompted the divorce between Branagh and Thompson, who had been married for five years at the time.
The script of 'The Misfits' (1961) was based on a story by playwright Arthur Miller, who was married to Marilyn Monroe at the time.
The actress wasn't happy about the script, however, and the constant tension between the two culminated in divorce immediately after they ended the production.
And her co-star Dean McDermott was married to Mary Jo Eustace. Until, of course, Spelling and MacDermott started an affair.
Tori Spelling was married to Charlie Shanian when she starred in this TV movie.
'Mind Over Murder' (2005) wrecked two marriages. And while Spelling and McDermott went on to be married for 18 years, Spelling eventually filed for divorce on March 29, 2024.
Sources: (Screen Crush)
Hollywood heartthrob Humphrey Bogart was married to fellow actress Mayo Methot at the time.
But their marriage reportedly wasn't in great shape, with the media dubbing the couple as the "battling Bogarts." Then the actor met Lauren Bacall on set of 'To Have and To Have Not.'
Bogart fell for Bacall and divorced Methot. The new couple stayed married until the actor died in 1957.
Though the actors reportedly couldn't stand each other, things changed when they co-starred in this movie. They were both married at the time: Elizabeth Taylor to Eddie Fisher, and Richard Burton to Sybil Williams.
The actors divorced their spouses to stay together. Taylor and Burton were married from 1964 to 1974, and then remarried in 1975 and got divorced again in 1976.
'Cleopatra' (1963) brought together two famous Hollywood stars: Elizabeth Taylor and Richard Burton.
The two actors quickly fell in love with each other, leading to Cruise getting a divorce just one month after he started filming 'Days of Thunder' (1990).
Tom Cruise was married to Mimi Rogers when he met his co-star Nicole Kidman.
The couple got married in 2005 and they stayed together for 13 years—and had three kids—until their divorce in 2018.
Director James Cameron was married to Linda Hamilton when he started working with actress Suzy Amis (who played Rose's granddaughter).
The two fell in love, Cameron got divorced, and the couple remain married until this day.
Actress Ali MacGraw was married to producer Robert Evans when she starred in the movie...until she met her co-star, Steve McQueen.
The actress was married to sculptor Gordon Anderson, and remained with him until her death in 2018. Eastwood, on the other hand, divorced his wife.
This movie was supposed to be Marilyn Monroe's affirmation as a more serious actress. It was her last on-screen performance.
Clint Eastwood was married to Maggie Johnson at the time, but fell in love with his co-star Sondra Locke while filming 'The Outlaw Josey Wales' (1976).
The two had an affair on the set of 'The Getaway,' which led to MacGraw's divorce. McQueen and MacGraw tied the knot in 1973, and were together for five years.
Jennifer Garner was married to Ben Foley and Ben Affleck was engaged to Jennifer Lopez, when the two started shooting 'Daredevil' (2003). Like their characters, the actors had great chemistry, so the romance was inevitable. Garner got a divorce and Affleck separated from J. Lo.
Cruise and Kidman got married later the same year, but they eventually called it quits in in 2001.
Many celebrity couples got together on set, but for some, the price to pay was the end of their previous marriages. Hollywood is full of love stories, but the truth is that some of these are way messier than we imagine. It's never fun when families get destroyed in the name of love, but sometimes there is no other way.
Click through and discover the movies that ruined real-life marriages.
When on-screen roles affected real-life relationships
Hollywood love affairs that had serious off-screen repercussions
MOVIES Hollywood couples
Many celebrity couples got together on set, but for some, the price to pay was the end of their previous marriages. Hollywood is full of love stories, but the truth is that some of these are way messier than we imagine. It's never fun when families get destroyed in the name of love, but sometimes there is no other way.
Click through and discover the movies that ruined real-life marriages.