▲James Franco regrets not taking his girlfriend to the hospital when his cat scratched her eye. The actor was busy with work, so he sent his assistant instead.

▲The actress regrets cheating on then-boyfriend Robert Pattinson with director Rupert Sanders.

▲The pop star regrets her marriage to dancer Kevin Federline.

▲The actor regrets cheating on Sienna Miller with his children's nanny.

▲The actress doesn't seem to be able to get over her ex Dominic Cooper.

▲The actor was caught cheating on Liz Hurley with a prostitute and deeply regrets it.

▲J.Lo said her failed marriage with ex-husband Marc Anthony was the biggest disappointment of her life.

▲Kim Kardashian once said that her biggest relationship regret was not dating Kanye West sooner. That answer has likely changed since then!

▲He deeply regrets losing Hilary Duff, whom he has called "the love of his life."

▲On cheating on Beyoncé, Jay-Z said, "The hardest thing is seeing the pain on someone's face that you caused, and then have to deal with yourself."

▲She regrets not dating her 'Sabrina the Teenage Witch' film co-star Ryan Reynolds.

▲The late actor never really got over Sally Field. He told Vanity Fair she was the love of his life.

▲Nick Viall of 'The Bachelor' regrets revealing on national television that he slept with Andi Dorfman.

▲Lori Loughlin "could be the one that got away" for the actor.

▲The actress regrets screwing up so many relationships.

▲The actor wishes he had listened more in his relationships.

▲"The one regret, if I had to do it over, would be divorcing Robert Kardashian," she told New You magazine.

▲The actress's biggest relationship regret is dating Will Smith while he was still married.

▲The DJ regrets taking on Twitter when he and Taylor Swift broke up.

▲"In divorce you always have regret," the actress said about her divorce from David Arquette.

▲The veteran actor shared how he regrets taking Catherine Zeta-Jones for granted after their temporary split.

▲The singer apologized numerous times to Paula Patton for his alleged cheating, but to no avail.

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Jef Holm regrets breaking up with Bachelorette Emily Maynard.

▲The Prince of Darkness regrets cheating on his wife, Sharon Osbourne.

▲The actress regrets how she handled her breakup with Macaulay Culkin.

▲The heartthrob regrets how his relationship with Jennifer Aniston came to an end. Pitt confessed that their marriage could have ended in a "more thoughtful manner.”

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In April 2020, the actor opened up about his divorce from Jennifer Garner. "The biggest regret of my life is this divorce. Shame is really toxic," he shared.

▲Kidman marvels at how young she was when she married Tom Cruise. The actress was 23.

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Lamar Odom seems to regret his past behavior with Khloé Kardashian more every day. The former basketball star opened up about his ex in a sneak peek of 'Celebrity Big Brother,' in which he's seen speaking to fellow houseguest Todrick Hall.

"I dreamt [about] my ex-wife last night," Odom says, and when Hall asks who he's referring to, and how many ex-wives he has, the NBA alum replies, "Just the one and only."

When Hall realizes he's talking about Kardashian, he asks if the two still talk, and Odom says, "No, I miss her so much." He then admits, "I wish I could take that time back." This wasn't the first time Odom has expressed his regret.

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Regrets—we all have them. There's always something we wish we would have done differently. When it comes to relationships, these regrets can haunt us for some time, but we can also learn from our mistakes and use them as a catalyst for change, for better relationships in the future.

Celebrities also have their breakups and makeups, and even they regret some things they've said or done in the past. Whether they let that special someone get away, or ended up cheating, there are many famous people who still regret their actions to this day.

Browse through the gallery and get to know your favorite stars' relationship regrets.

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Madonna recently answered 50 fan questions on her YouTube channel to promote her new album, 'Finally Enough Love.' One fan asked the singer to reveal a decision she made in the past that she now feels wasn't the best. Madonna answered, "Getting married. Both times." The Queen of Pop has been married twice, first to Sean Penn from 1985 and 1989, and then to director Guy Ritchie from 2000 to 20008.

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In regards to her marriage to Ritchie, the singer said, "I stepped into a soap opera, and I lived in it for quite a long period of my life." Not a great review! Sean Penn is a more complicated figure in her life. Madonna has publicly showered him with praise and expressed her love for him in the decades since their divorce, even jokingly offering to re-marry him. They seem to be on excellent terms, despite rumors of physical abuse within their marriage.

Madonna says that while her marriages were perhaps not her best ideas, she has zero doubts about her family, saying that her six children are her proudest achievements.