POLG mitochondrial disease is a rare genetic disorder caused by mutations in the POLG gene, which is responsible for maintaining the DNA of mitochondria. This disease severely disrupts the body's ability to produce energy, leading to muscle weakness, neurological issues, and even organ failure. With no cure, patients often face a gradual and debilitating decline in health.
Prince Frederik of Luxembourg, the youngest son of Prince Robert of Luxembourg and Princess Julie of Nassau, passed away at 22 on March 1, after years of struggling with POLG mitochondrial disease. Diagnosed at age 14, his journey highlighted the challenging and progressive nature of the condition.
Click on to learn more about this rare disease.