▲This rom-com, which famously used AOL email accounts to drive the love plot, saw Ryan and Hanks' chemistry both in type and while at each other's throats. Even with technology evolving, this recurring on-screen affair remains timeless.

▲An instant love story for the ages, this film is also fondly remembered for Ryan's steamy scene in a New York deli.

▲Ryan was playful as ever in this rom-com, which centers on a mechanic (Robbins) and a Princeton doctoral candidate (Ryan) who fall in love, with the aid of the student's uncle, Albert Einstein.

▲Ryan's first lengthy and graphic love scene was in this mystery thriller film, in which she plays a college English professor who becomes entangled with a detective investigating a series of gruesome murders in her neighborhood.

▲In this satirical comedy, Ryan plays a feisty project developer helping Macy's character make a film in South Africa, which involves some very unpredictable bumps along the way, and a strangely happy ending.

▲As the mother of an FBI agent, Ryan's character unknowingly falls in love with a criminal, who (spoiler alert) ends up being a good guy. Phew!

▲For this film, Ryan played a mother and wife facing breast cancer, who also happens to get involved with her neighbor's grandson, played by Adam Brody.

▲Reuniting with her fiancé from 'French Kiss,' Ryan plays a high-powered attorney and high-key maniac. She finds out her husband is about to leave her for someone else, and decides to tape him to a toilet! Ryan pulls off a wicked twist at the end.

▲During the production of this action thriller film, Crowe and Ryan reportedly had a romantic affair. At the time, Ryan was married to Dennis Quaid, but the two divorced within a year. Ironically, Ryan's character in this film grows attracted to a man (Crowe) who is helping her save her husband.

▲Combine two charming talents with a sharp comedy writer who handles love seamlessly (Nora Ephron), and you get magic. This film took a chance in keeping its leads separate for most of the time, but when they meet, it's at the top of the Empire State Building.

▲In this film about a man who is diagnosed with a fatal “brain cloud,” Ryan actually plays three characters. The now-cult classic was the first display of her chemistry with Hanks, and it was enough to get them in a few more flicks together.

▲In this American biopic about the iconic band, Ryan plays Pamela Courson, Jim Morrison's companion.

▲Ryan's performance as an alcoholic mother and high school guidance counselor earned her a Screen Actors Guild Award nomination for Best Female Actor. She is both lighthearted and loving, as well as reckless and neglectful, and her on-screen husband's dedication to help her is heartbreaking.

▲Two vengeful people get together and try to break apart the envied union of their respective former partners, including everything from identity theft to assault. Naturally, they both start falling for each other along the way.

▲This romantic fantasy tells the story of an angel (Cage) who falls in love with a mortal woman and surgeon (Ryan). He wishes to become human in order to be with her.

▲Years after their box-office hits, Ryan decided to debut as a director, as well as star alongside her old friend. In 'Ithaca,' she plays a widow, and Hanks is her dead husband.

▲In this hilarious film, Ryan plays a woman who flies to France to confront her straying fiancé. She then gets into some gorgeously-framed trouble with a charming crook.

▲Ryan plays Quaid's estranged girlfriend and eventual wife in this sci-fi comedy. Everyone wonders if they knew in that last scene that they, in real life, would later be married as well.

▲In this crime-thriller, Ryan plays a student and Quaid a professor, and they get wrapped up in a very complicated murder plot. The actors are said to have fallen in love during the shoot!

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Though they only share a fleeting moment together on screen, Washington and Ryan shine as leads in this war film where he must determine if she should be the first woman to receive a posthumous Medal of Honor.

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This fantasy rom-com tells the story of a duke who travels through time from New York in 1876 to the present, falling in love with a modern woman played by the ever-eccentric Ryan.

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In this neo-noir drama, Ryan plays a woman who leaves her gambling husband for a man that ends up being the reason her entire family was murdered when she was young.

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In this historic drama, Ryan plays a troubled young woman whose husband leaves her. Enter Robert Downey Jr., whose character takes her on as a lover, only to lose her when she gives birth to their child.

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Ryan plays the wife of Anthony Edwards' character in this film. The actors actually began dating after meeting on set.

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In this drama-comedy about a trio of sisters (Meg Ryan, Diane Keaton, and Lisa Kudrow) who bond over their father's impending death, Arkin's character has a small but warming presence.

Delve into Lisa Kudrow's most famous role here.

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Ryan plays the unrestrained, unpredictable, and overbearing bride to Sutherland in this romantic drama.

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The romantic arc of Steve Andropoulos and Betsy Stewart on the popular soap opera set a new standard for TV. The fictional couple wed on May 30, 1984, and the episode attracted 20 million viewers, making it the second-highest-rated hour in American soap opera history.

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In this strange romantic fantasy film, Ryan plays a liberal aspiring graphic designer who marries a conservative publisher. At their wedding, they are approached by an old man who requests to kiss her, and they switch souls, leaving the groom with an aged man's soul inside his new bride.

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Meg Ryan began her acting career in 1981 and became America’s sweetheart by the ‘90s, reigning undefeated in the realm of rom-coms. Her on-screen chemistry is unparalleled, and we love to watch her love—in all her eccentric, quirky, and knee-weakening ways.

We've missed her talents for a whole 13 years, but thankfully she is returning to the genre as both star and director! The actress is starring in the upcoming romantic comedy 'What Happens Later,' co-starring 'The X-Files' actor David Duchovny.

While we wait for the movie's release, check out this gallery to look back on those she's shared her spark with on screen.