'Grey's Anatomy' began airing in 2005. The show explores modern medicine through the eyes of its characters. Created by Shonda Rhimes, the medical drama just had its season 22 premiere on October 9. Indeed, beloved and hated characters have come and gone, but the drama remains.
But even though the show has an incredibly long legacy, it's not the only series out there that has been on the air for an impressively long time. Click through this gallery to see the world's longest-running TV shows.