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Dave Starsky and Ken 'Hutch' Hutchinson - 'Starsky & Hutch' (1975-1979) - Paul Michael Glaser and David Soul starred as Starsky and Hutch in this timeless comedy. The two cops fought crime throughout the series' 92 episodes, all with the help of their iconic red Ford Gran Torino.

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Derek Zoolander and Hansel - Zoolander films - In this fashion satire, Ben Stiller plays Derek Zoolander, a model who's reaching the end of his career. On the other hand, Owen Wilson plays Hansel, who's going through his best modeling years. The 2001 comedy was such a hit that it got a sequel in 2016.

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Spock and Kirk - Star Trek franchise - Several actors have given life to the popular Star Trek characters of Spock and Kirk. Most recently, Zachary Quinto and Chris Pine have played the pair on the big screen.

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Mike and Sulley - Monsters, Inc. franchise - This dynamic duo (voiced by Billy Crystal and John Goodman, respectively) are in charge of scaring little kids at night, as that's the only way to provide power for their city. A prequel, 'Monsters University,' was released in 2013, and a TV series, 'Monsters at Work,' premiered in 2021.

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Lorelai and Rory Gilmore - 'Gilmore Girls' - Lauren Graham and Alexis Bledel respectively play mother and daughter on the show. Their incredibly strong bond is at the core of 'Gilmore Girls,' which was so successful it even got its own reboot in 2016.

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Evan and Seth - 'Superbad' (2007) - Michael Cera and Jonah Hill are two teen best friends who have to go their separate ways as they enroll for college. They decide to celebrate their friendship by attending a party, and their night ends up turning into a legendary adventure.

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Dale Denton and Saul Silver - 'Pineapple Express' (2008) - This unlikely duo is comprised of process server Dale Denton (Seth Rogen) and his drug dealer Saul Silver (James Franco). The two find themselves on the run from both hitmen and the police after Denton witnesses a crime while picking up weed from Silver.

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Sydney Fife and Peter Klaven - 'I Love You, Man' (2009) - Paul Rudd plays Peter Klaven, a man with no friends who's on a quest to find a best man for his own wedding. That's when he finds Sydney Fife (Jason Segel), with whom he builds a strange but honest relationship.

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Karen Walker and Jack McFarland - 'Will & Grace' (1998-2020) - Megan Mullally plays the wealthy, alcohol-loving socialite, while Sean Hayes is the eccentric and incredibly dramatic Jack. The pair are Will and Grace's besties, in what was one of the best comedy sitcoms to come out of the late '90s.

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Chewbacca and Han Solo - Star Wars films -

These two are one of the most iconic movie duos ever. Chewbacca is a Wookie and the loyal friend of Han Solo (Harrison Ford), a smuggler and skillful pilot. In 2018, Han Solo got his own spin-off with the film 'Solo: A Star Wars Story.' Solo was played by Alden Ehrenreich.

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Woody and Buzz Lightyear - Toy Story films - Tom Hanks and Tim Allen voiced these beloved animated characters. Woody was used to being his owner's favorite toy, but it all changed with Buzz's arrival. However, when they find themselves in a complicated situation, they overcome their rivalry and realize they're much stronger together.

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Sheldon Cooper and Amy Farrah Fowler - 'The Big Bang Theory' (2007-2019) - Jim Parsons and Mayim Bialik form a power couple who are as smart as they are funny! It took these two awhile, but we were thrilled when they finally got their happy ending.

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Dana Scully and Fox Mulder - The X-Files franchise - Gillian Anderson and David Duchovny are two FBI agents who investigate strange crimes that are connected to paranormal activity. The iconic TV show debuted in 1993, ran until 2002, had a few films, and then returned in 2016 to the delight of its cult following of fans.

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Lisa and Susanna - 'Girl, Interrupted' (1999) - Winona Ryder plays the role of Susanna, a young woman who's required to spend 18 months in a psychiatric hospital. There, she meets Lisa (Angelina Jolie), a sociopath who convinces her to stop taking her meds and resist treatment. Jolie ended up winning an Oscar for Best Supporting Actress for her performance in the movie.

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J and K - Men In Black films - Will Smith and Tommy Lee Jones play two secret agents for the MIB, a secret organization that monitors alien activity on Earth. The comedy movie was so successful it resulted in two more sequels.

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Jay and Silent Bob - 'Jay and Silent Bob Strike Back' (2001) and more - Jason Mewes and Kevin Smith portray two friends who are constantly stoned. Their characters first appeared in the movie 'Clerks' in 1994, and since then they've had their own movies and made cameo appearances in other projects, too.

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Marcus Burnett and Mike Lowrey - Bad Boys films -

Martin Lawrence and Will Smith play two detectives who must protect a witness at all costs. 'Bad Boys' had two sequels, and there are talks of a fourth.

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Dominic Toretto and Brian O'Conner - Fast & Furious films -

Vin Diesel and Paul Walker were one of the most charismatic duos in recent Hollywood history. In total, they starred in seven of the Fast & Furious movies. Sadly, Walker died in 2013 following a car accident.

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Kermit and Miss Piggy - The Muppets franchise - The Muppets have been around for a while and two of their most beloved characters are Kermit and Miss Piggy, who have an unusual romance.

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Tyler Durden and The Narrator - 'Fight Club' (1999) -

Brad Pitt and Edward Norton play the lead characters in this action-fueled movie, where two very different men end up sharing one thing in common: a taste for illegal fighting.

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Sherlock Holmes and Dr. John Watson - Sherlock Holmes franchise - Many actors have played the detective Sherlock Holmes and his sidekick Dr. Watson throughout the years. Robert Downey Jr. and Jude Law got to play these iconic roles in the most recent big screen productions.

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The Tramp and the Child - 'The Kid' (1921) - Charlie Chaplin portrays a tramp who strikes a friendship with a homeless kid (Jackie Coogan). They still remain as one of the rawest and most entertaining duos in history.

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Brennan Huff and Dale Doback - 'Step Brothers' (2008) - Will Ferrell is Brennan, a 40-year-old unemployed singleton who still lives with his mother, Nancy. John C. Reilly plays the role of Dale, who's in the same situation as Brennan, but lives with his father, Robert. The two are forced to endure each other when their parents fall in love and decide to get married.

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Torrance Shipman and Missy Pantone - 'Bring It On' (2000) - Kirsten Dunst is Torrance, the captain of her high school's cheerleading squad. For the next competition, she must come up with the perfect routine, and Missy Pantone (Eliza Dushku) turns out to be a great addition to the team.

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Marty McFly and Dr. Emmett Brown - Back to the Future films - Michael J. Fox and Christopher Lloyd respectively brought to life these two incredible characters. The teenager and the eccentric scientist embark on a time-traveling journey, proving that their friendship can survive not only in the present but also in the past and future!

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Indiana Jones and Professor Henry Jones - 'Indiana Jones and the Last Crusade' (1989) - Played by Harrison Ford, the adventurous archaeologist Indiana Jones needs no introduction. When his father Henry Jones (Sean Connery) disappears, Indiana embarks on a quest to find him. The two make for a hilarious and brave duo.

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Billy and Wyatt - 'Easy Rider' (1969) - Two hippy motorcyclists travel together from Los Angeles to New Orleans to carry out a drug deal. Peter Fonda plays Wyatt, while Dennis Hopper plays Billy.

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Butch Cassidy and the Sundance Kid - 'Butch Cassidy and the Sundance Kid' (1969) - Paul Newman and Robert Redford starred as two of the most infamous outlaws during the early 1900s, in what is considered by many to be one of the greatest movies of all time.

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Nicholas Angel and Danny Butterman - 'Hot Fuzz' (2007) -

Simon Pegg and Nick Frost are two cops trying to solve a mysterious murder in a quaint English village. Their chemistry has made them one of the most popular on-screen duos ever. They appeared in many other successful comedies like 'Shaun Of The Dead' (2004) and 'The World's End' (2013).

Sources: (ScreenRant) (Wonderwall)

See also: On-screen friends who became inseparable in real life

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