






























See Also
See Again
© Shutterstock
0 / 31 Fotos
Studying the syndrome
- A study of several families with Laron syndrome (LS) in Ecuador has opened up the possibility of developing a drug or diet that could mimic its beneficial effects, according to a report published in El País.
© Getty Images
1 / 31 Fotos
How does Loran syndrome develop?
- LS is an incredibly rare congenital disorder characterized by marked short statue. The condition results from the body's inability to use growth hormone. It is usually caused by inherited growth hormone receptor (GHR) mutations.
© Shutterstock
2 / 31 Fotos
Slow growth
- While affected individuals are close to normal size at birth, they experience slow growth from early childhood. Adult males typically reach a height of 4 ft 10 in (1.5 m) and adult females 4 ft (1.2 m).
© Getty Images
3 / 31 Fotos
Craniofacial abnormality
- Besides being well below median height, those with LS display other malformations, including craniofacial abnormalities.
© Shutterstock
4 / 31 Fotos
Thin hair
- Hair that is thin and fragile is indicative of the condition, as are dental abnormalities.
© Shutterstock
5 / 31 Fotos
Hypoglycemia
- Laron syndrome can also induce low blood sugar levels in infancy, leading to hypoglycemia.
© Shutterstock
6 / 31 Fotos
Short limbs
- Affected individuals have short limbs compared to the size of their torso, as well as small hands and feet.
© Shutterstock
7 / 31 Fotos
Obesity
- Adults with Laron syndrome tend to develop obesity. This is due to changes in metabolism caused by insensitivity to growth hormone and the resulting shortage of insulin growth factor 1 (IGF-1).
© Shutterstock
8 / 31 Fotos
Reduced risks of disease
- Despite these raft of symptoms, evidence has suggested that people with Laron syndrome have a significantly reduced risk of developing a number of life-threatening medical conditions, including cancer.
© Shutterstock
9 / 31 Fotos
Type 2 diabetes
- People with LS people also appear to be less inclined to develop diabetes mellitus type II.
© Shutterstock
10 / 31 Fotos
Lower levels of arteriosclerosis plaques
- Furthermore and despite demonstrating high levels of "bad" LDL cholesterol, they have far fewer arteriosclerosis plaques—the substance that causes arteries to narrow, blocking blood flow. This is according to the medical science journal Med.
© Shutterstock
11 / 31 Fotos
Cardiovascular disease
- And studies suggest that the Laron mutation also has a protective effect against cardiovascular diseases.
© Shutterstock
12 / 31 Fotos
What causes LS?
- Laron syndrome is caused by mutations in the GHR gene. This gene provides instructions for making a protein called the growth hormone receptor.
© Shutterstock
13 / 31 Fotos
How does LS evolve?
- When a growth hormone is bound to its receptor, it triggers signaling that stimulates the growth and division of cells. It also produces another important growth-promoting hormone called insulin-like growth factor I (IGF-I).
© Public Domain
14 / 31 Fotos
The positive side of LS
- Mutations in the GHR gene impair the receptor's ability to bind to growth hormones or to trigger signaling within cells. Researchers are working to determine how mutations in the GHR gene may protect people with Laron syndrome from developing diseases such as cancer and type 2 diabetes.
© Shutterstock
15 / 31 Fotos
Related to aging
- It does appear that Laron's mutation protects against diseases related to aging.
© Shutterstock
16 / 31 Fotos
The contradictions of LS
- Studies have showed that people affected by the syndrome produced less IGF-1, a protein essential for childhood growth but which in adults also promotes uncontrolled cancer cell proliferation.
© Shutterstock
17 / 31 Fotos
The role diet plays
- Biochemists, meanwhile, are looking at diets that mimic fasting, which lower IGF-1 levels in circulated blood—the supposed cause of the beneficial effects observed in people with Laron.
© Shutterstock
18 / 31 Fotos
How LS is inherited
- Laron syndrome is recessive. In other words, you have to inherit two mutated copies of the gene, one from the father and one from the mother, to suffer from it.
© Shutterstock
19 / 31 Fotos
Inheritance lottery
- It's quite possible for one person with the syndrome to have healthy children. Similarly, it is also possible for two people without the syndrome to carry the mutation and have children with LS.
© Getty Images
20 / 31 Fotos
LS around the world
- Laron syndrome is a very rare condition. About 350 people have been diagnosed with the disorder worldwide. The largest single group of affected individuals (about 100 people) live in an area of southern Ecuador. The second largest group (69 individuals) live in Israel.
© Shutterstock
21 / 31 Fotos
LS promoted through endogamy
- Endocrinologists working in isolated towns in the provinces of Loja and El Oro, in the south of Ecuador, have ascertained that in these communities, endogamy—the custom of marrying only within the limits of a local community, clan, or tribe—is commonplace. This custom has facilitated the spread of the syndrome.
© Getty Images
22 / 31 Fotos
Zvi Laron, LS pioneer
- Laron syndrome was discovered in 1966 by Israeli pediatric endocrinologist Zvi Laron. His pioneering research opened the way to the treatment of many cases of growth hormone disorders. Over the years, Laron has published several studies focused on how to replicate the cancer-protective effects he sees in patients afflicted by LS.
© Getty Images
23 / 31 Fotos
No treatment, no cure
- There is no treatment that prevents the onset of Laron syndrome, nor is there a cure.
© Shutterstock
24 / 31 Fotos
Catching the condition early
- Furthermore, people with Laron syndrome are generally unresponsive to growth hormone therapy. However, there are drugs available that if administered before puberty can be effective.
© Shutterstock
25 / 31 Fotos
Managing the disorder
- Management and treatment of the condition aims at improving growth in children.
© Shutterstock
26 / 31 Fotos
Daily injections
- This includes treatment with daily subcutaneous injections of mecasermin (a recombinant human insulin-like growth factor-1) and recombinant human IGF-I.
© Shutterstock
27 / 31 Fotos
High-calorie diet
- A diet with adequate calorie intake is also important. Frequent feeding is necessary in order to avoid hypoglycemia.
© Shutterstock
28 / 31 Fotos
Research continues
- Back in Ecuador, researchers are trying to establish a large-scale diagnosis system that would allow the inhabitants of the communities affected to know if their partners are carriers of the mutation.
© Getty Images
29 / 31 Fotos
Potential global health benefits
- The long-term goal is to identify methods of transferring the health benefits of Laron syndrome to the general population. Sources: (El País) (Med) (MedlinePlus) (National Institutes of Health) (ScienceDirect)
© Shutterstock
30 / 31 Fotos
© Shutterstock
0 / 31 Fotos
Studying the syndrome
- A study of several families with Laron syndrome (LS) in Ecuador has opened up the possibility of developing a drug or diet that could mimic its beneficial effects, according to a report published in El País.
© Getty Images
1 / 31 Fotos
How does Loran syndrome develop?
- LS is an incredibly rare congenital disorder characterized by marked short statue. The condition results from the body's inability to use growth hormone. It is usually caused by inherited growth hormone receptor (GHR) mutations.
© Shutterstock
2 / 31 Fotos
Slow growth
- While affected individuals are close to normal size at birth, they experience slow growth from early childhood. Adult males typically reach a height of 4 ft 10 in (1.5 m) and adult females 4 ft (1.2 m).
© Getty Images
3 / 31 Fotos
Craniofacial abnormality
- Besides being well below median height, those with LS display other malformations, including craniofacial abnormalities.
© Shutterstock
4 / 31 Fotos
Thin hair
- Hair that is thin and fragile is indicative of the condition, as are dental abnormalities.
© Shutterstock
5 / 31 Fotos
Hypoglycemia
- Laron syndrome can also induce low blood sugar levels in infancy, leading to hypoglycemia.
© Shutterstock
6 / 31 Fotos
Short limbs
- Affected individuals have short limbs compared to the size of their torso, as well as small hands and feet.
© Shutterstock
7 / 31 Fotos
Obesity
- Adults with Laron syndrome tend to develop obesity. This is due to changes in metabolism caused by insensitivity to growth hormone and the resulting shortage of insulin growth factor 1 (IGF-1).
© Shutterstock
8 / 31 Fotos
Reduced risks of disease
- Despite these raft of symptoms, evidence has suggested that people with Laron syndrome have a significantly reduced risk of developing a number of life-threatening medical conditions, including cancer.
© Shutterstock
9 / 31 Fotos
Type 2 diabetes
- People with LS people also appear to be less inclined to develop diabetes mellitus type II.
© Shutterstock
10 / 31 Fotos
Lower levels of arteriosclerosis plaques
- Furthermore and despite demonstrating high levels of "bad" LDL cholesterol, they have far fewer arteriosclerosis plaques—the substance that causes arteries to narrow, blocking blood flow. This is according to the medical science journal Med.
© Shutterstock
11 / 31 Fotos
Cardiovascular disease
- And studies suggest that the Laron mutation also has a protective effect against cardiovascular diseases.
© Shutterstock
12 / 31 Fotos
What causes LS?
- Laron syndrome is caused by mutations in the GHR gene. This gene provides instructions for making a protein called the growth hormone receptor.
© Shutterstock
13 / 31 Fotos
How does LS evolve?
- When a growth hormone is bound to its receptor, it triggers signaling that stimulates the growth and division of cells. It also produces another important growth-promoting hormone called insulin-like growth factor I (IGF-I).
© Public Domain
14 / 31 Fotos
The positive side of LS
- Mutations in the GHR gene impair the receptor's ability to bind to growth hormones or to trigger signaling within cells. Researchers are working to determine how mutations in the GHR gene may protect people with Laron syndrome from developing diseases such as cancer and type 2 diabetes.
© Shutterstock
15 / 31 Fotos
Related to aging
- It does appear that Laron's mutation protects against diseases related to aging.
© Shutterstock
16 / 31 Fotos
The contradictions of LS
- Studies have showed that people affected by the syndrome produced less IGF-1, a protein essential for childhood growth but which in adults also promotes uncontrolled cancer cell proliferation.
© Shutterstock
17 / 31 Fotos
The role diet plays
- Biochemists, meanwhile, are looking at diets that mimic fasting, which lower IGF-1 levels in circulated blood—the supposed cause of the beneficial effects observed in people with Laron.
© Shutterstock
18 / 31 Fotos
How LS is inherited
- Laron syndrome is recessive. In other words, you have to inherit two mutated copies of the gene, one from the father and one from the mother, to suffer from it.
© Shutterstock
19 / 31 Fotos
Inheritance lottery
- It's quite possible for one person with the syndrome to have healthy children. Similarly, it is also possible for two people without the syndrome to carry the mutation and have children with LS.
© Getty Images
20 / 31 Fotos
LS around the world
- Laron syndrome is a very rare condition. About 350 people have been diagnosed with the disorder worldwide. The largest single group of affected individuals (about 100 people) live in an area of southern Ecuador. The second largest group (69 individuals) live in Israel.
© Shutterstock
21 / 31 Fotos
LS promoted through endogamy
- Endocrinologists working in isolated towns in the provinces of Loja and El Oro, in the south of Ecuador, have ascertained that in these communities, endogamy—the custom of marrying only within the limits of a local community, clan, or tribe—is commonplace. This custom has facilitated the spread of the syndrome.
© Getty Images
22 / 31 Fotos
Zvi Laron, LS pioneer
- Laron syndrome was discovered in 1966 by Israeli pediatric endocrinologist Zvi Laron. His pioneering research opened the way to the treatment of many cases of growth hormone disorders. Over the years, Laron has published several studies focused on how to replicate the cancer-protective effects he sees in patients afflicted by LS.
© Getty Images
23 / 31 Fotos
No treatment, no cure
- There is no treatment that prevents the onset of Laron syndrome, nor is there a cure.
© Shutterstock
24 / 31 Fotos
Catching the condition early
- Furthermore, people with Laron syndrome are generally unresponsive to growth hormone therapy. However, there are drugs available that if administered before puberty can be effective.
© Shutterstock
25 / 31 Fotos
Managing the disorder
- Management and treatment of the condition aims at improving growth in children.
© Shutterstock
26 / 31 Fotos
Daily injections
- This includes treatment with daily subcutaneous injections of mecasermin (a recombinant human insulin-like growth factor-1) and recombinant human IGF-I.
© Shutterstock
27 / 31 Fotos
High-calorie diet
- A diet with adequate calorie intake is also important. Frequent feeding is necessary in order to avoid hypoglycemia.
© Shutterstock
28 / 31 Fotos
Research continues
- Back in Ecuador, researchers are trying to establish a large-scale diagnosis system that would allow the inhabitants of the communities affected to know if their partners are carriers of the mutation.
© Getty Images
29 / 31 Fotos
Potential global health benefits
- The long-term goal is to identify methods of transferring the health benefits of Laron syndrome to the general population. Sources: (El País) (Med) (MedlinePlus) (National Institutes of Health) (ScienceDirect)
© Shutterstock
30 / 31 Fotos
What is Laron syndrome, and can it really protect us from cancer and diabetes?
This rare disorder has remarkable health benefits
© Shutterstock
Laron syndrome (LS) is an extremely rare medical disorder characterized by short stature and other physical abnormalities. Yet those afflicted with LS appear to be immune to a range of life-threatening conditions, including cancer, diabetes, and cardiovascular disease. LS is so rare that just 350 known cases have been recorded globally. Interestingly, a disproportionate number of these live in Ecuador. And it's in this South American nation that researchers are working on ways to harness LS' beneficial health effects. So, what causes this uncommon condition, and why is a genetic mutation proving so effective against some of our most notorious illnesses?
Click through this gallery and learn more about this little-known medical anomaly.
RECOMMENDED FOR YOU




































MOST READ
- Last Hour
- Last Day
- Last Week